Paresthesia is a side effect that can be caused by which supplement?

Paresthesia, which is a sensation of tingling or prickling, is primarily associated with beta-alanine supplementation. This sensation typically occurs when beta-alanine is consumed in higher doses, often observed at levels above 800 mg. The mechanism behind this side effect is related to the way beta-alanine influences the nervous system, particularly in relation to the stimulation of nerve endings.

When beta-alanine enters the bloodstream, it increases the level of carnosine in muscle tissue, which can help enhance performance, especially during high-intensity exercise. However, the buildup of beta-alanine in the bloodstream can lead to hyperstimulation of sensory neurons, resulting in the tingling sensation often reported by users.

In contrast, while caffeine may have other side effects like jitters or increased heart rate, it does not commonly result in paresthesia. Creatine is known for its various benefits related to strength and energy, but it does not typically cause this tingling sensation. Omega-3 fatty acids, primarily associated with heart and brain health, have few side effects and are not linked to paresthesia. Thus, beta-alanine stands out as the supplement in this context most closely associated with this specific side effect.